Welcome to the Nickells Lab
The primary focus of the lab is to study the molecular pathology of retinal ganglion cell death after injury to the optic nerve with an ultimate goal to develop therapeutic approaches to attenuate ganglion cell death in common optic nerve diseases like glaucoma. A principal area of research is to understand the roles played by the BCL2 gene family of proteins, which control the intrinsic apoptotic pathway. Our research employs a variety of mouse models of disease including controlled acute optic nerve injury and chronic inherited glaucoma.
